Tuesday, April 30, 2024

NFL Draft 2024: UGA tight end Brock Bowers drafted by Las Vegas Raiders in first round WSB-TV Channel 2 Atlanta

dawg house

Drake is such an indomitable force in rap that it takes a whole army of foes to join forces and make a coordinated effort just to attack him, and even then, he still finds a way to fire back against them all. He transforms the original Metro-produced beat by adding a choir of Inter Milan hooligans, in the same way that he did on his No. 1 song “Carnival,” which makes it feel like it could have soundtracked a blockbuster movie trailer. But sadly, it’s less like Tarantino’s The Hateful Eight and more like Marvel’s Ant-Man 3.

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Your buddy can’t exactly tell you why he pees in the crate when you’re not home, though, and you can't always catch him in the act — so it can be tricky.Luckily, with a keen eye and a few trial runs, you’ll figure out the problem in no time. You can always enlist your family, vet, or local doggie daycare to keep an eye out, too, but it’s up to you to make the necessary changes to change the behavior. Anything from a more consistent routine to a new treat-dispensing toy could be the difference between cleaning up a puddle or coming home to a happy pup.Here’s how to stop your dog from peeing in his crate. According to PetMD, a dog house is a perfect safe haven for fearful dogs. Keeping your dog out of direct sunlight during the summer is also beneficial, as dogs can easily overheat, and dogs with lighter-colored coats are at an increased risk of sunburn. Since Kendrick’s explosive verse on “Like That” acted as a signal flare for anybody who has problems with Drake to step forward and get at him.

Where should you put your dog house?

Some dog houses have doors on them, so if you want the most versatility, look for a dog house with a removable door to maximize air flow during hotter months. With an original location on Nashville’s Music Row, Dawg House Saloon is a classic Nashville sports bar perfect for those who love music and watching the game. Situated adjacent to the Resorts World Las Vegas sportsbook, the venue features live music and dancing, an array of draft beers, creative cocktails, and classic American pub fare with a Southern twist.

More from The Spruce Pets

Rappers like Rick Ross and Ye have answered the call, while Drake has been fighting back with his own responses (and AI?) to even the score. As we wait for more shots to land in the near future, here is a ranking of all of the direct diss tracks (not counting some of the more subliminal verses on We Still Don’t Like You) that have come out of this rap war so far. Before using these free dog house plans to build your dog's dream home, make sure that it will be the right fit for the size of your full-grown dog. Some of these plans can even be customized to fit any size of dog, so be sure to look for instructions within the plans for that. These 14 free DIY dog house plans will make sure that your dog has a safe haven from the weather and you can take pride that you built it just for them.

At Dawg House Saloon & Sports Book in Las Vegas, Southern-style food combines with drinks for a fine time - Las Vegas Magazine

At Dawg House Saloon & Sports Book in Las Vegas, Southern-style food combines with drinks for a fine time.

Posted: Mon, 25 Mar 2024 07:00:00 GMT [source]

Residence Hall Checkout Deadline For Residents Not Participating In Commencement

Browns fans are used to seeing the classic STARTER satin jackets, but today, for the first time ever, they have partnered with HOMAGE to release the first ever STARTER windbreakers! Bulldog Battle is a monthly competition for residents to show off their rooms leading to the annual Room of the Year vote in April. Log onto The Dawg House portal to register for housing, request a room change or manage your profile.

Pallet Dog House Plan

When you and you dog are out and about, your dog's collar is an important part of keeping them safe. It holds their tags, which has vital info that can help you reunite if your dog gets lost, is a convenient place to hold onto if the leash breaks, and it lets other people know that your dog isn't a stray if they get lost. Dr. Bartley Harrison is a veterinarian with more than 15 years of professional veterinary experience treating dogs, cats, rabbits, ferrets, birds, and small mammals, with a specific focus on Emergency Medicine. Dr. Harrison is part of The Spruce Pets’ veterinary review board. It has the nostalgic feel to it, but something like this is also timeless and feels like you’re wearing something special.

There are several actions that could trigger this block including submitting a certain word or phrase, a SQL command or malformed data. Firefighters set up tanker shuttles to attempt to ease the impact on the municipal water supply. As dawn broke Saturday morning, flames and smoke continued to billow out of the hollowed out walls of the massive structure, with four ladder trucks pouring water onto the wreckage. DETROIT, Mich. — University of Georgia TE Brock Bowers is the first Bulldog to be drafted in the 2024 NFL Draft. Physically present in AZ/CO/CT/IL/IN/IA/KS/KY/LA(select parishes)/MA/MD/ME/MI/NC/NH/NJ/NY/OH/OR/PA/TN/VA/VT/WV/WY only.

dawg house

This will help your dog stay cool during those hot summer months. Traditional dog houses serve their purpose, but they’re nothing special to look at. Fortunately, there’s no need for your dog to have a dull, run-of-the-mill dog house anymore. Today’s dog houses are designed to suit your dog’s size as well as your climate, ensuring your pooch stays perfectly comfortable all year long.

Let your unique dog house ideas come to fruition so your furry friend can relax in style. That way, he or she can chill in a fun, interesting space that will make your backyard infinitely more stylish — and keep your dog happy and comfortable in their home no matter the season. Yes, J. Cole loses points for apologizing for his diss at Kendrick Lamar and taking “7 Minute Drill” off of streaming. But even though Cole’s heart was never in the fight in the first place, his response to Kendrick’s “Like That” verse still out-paces some of the AI raps and self-indulging remixes that have followed it. There have already been half a dozen diss songs in the rap war between Drake, Kendrick Lamar, and more. We’re the only spot on the Las Vegas Strip where you’ll find a variety of live music and dancing with no cover charge!

And the lyrics are worse, as Ye spends the first half of the verse rapping about himself before firing off a few half-baked shots about Lucian Grainge, J. Cole, how he “can’t even think of a Drake line” (which is a lie). This remix falls in line with many of the lackluster verses that Ye has dropped recently, and it’s clear that he didn’t have much to add to this rap war, besides reigniting his long-running feud with Drake. As pet parents, we’d like to think that we have every solution for behavior issues, like how to stop a dog from peeing in his crate.

Are you looking for a dog house that will hold up to rainy weather without leaking? Plastic dog houses are lightweight, reasonably priced, and they come in a wide variety of unique designs. You can find plastic dog houses shaped like castles, miniature homes, and barns. Some dog houses even have built-in food and water bowls, so your dog won’t have to leave the comfort of their home for long to have a bite to eat. A good dog house will provide enough space for your dog to turn around comfortably. If you live in a warm, sunny climate with mild to moderate winters, you should ensure your dog has plenty of space inside of their home.

Modern Design, DIYed Photo Gallery & Ideas Trex

trex deck design ideas

'There is an increasing number of composite decking brands,' says Karl Harrison – pro landscaper and Trex decking expert, 'and some have been around for many years. It is these brands that can be relied upon for superior performance and quality of warranty. This works well for garden steps ideas, where the secondary color can be used to draw attention to the edges. Not only does it look good, but it will also help prevent people from accidentally missing a step. The way that this dark gray matches the door frames of the home makes for an eye-catching touch. As well as opting for composite decking in this scheme, think about painting your fence to match for a truly cohesive aesthetic.

Outdoor Dining Set & Chairs

Simple boardwalks and docks need not be so simple when you can choose from an array of beautiful greys, browns and reds. Match the dock to your home’s exterior or go completely against the grain. Sarah Lyon is a New York City-based freelancer who produces interior design, travel and lifestyle content. Her work is featured in outlets including Apartment Therapy, Architectural Digest, MyDomaine, The Washington Post and The New York Times.

36 decking ideas to recreate in your backyard - Yahoo Canada Finance

36 decking ideas to recreate in your backyard.

Posted: Sat, 06 Apr 2024 07:00:00 GMT [source]

#9: Mesh Magic Enhance the View with a Glass and Mesh Railing Design

Draw inspiration from features that involve water ideas and integrate one into your new decked patio for a really stylish garden makeover. Just make sure you choose ones that can withstand being exposed to the outdoors. Lavenders, olive trees, and beautiful grasses are all fine alternatives, but Japanese acers and ferns should be avoided.

Privacy Please Use Innovative Decking To Create a Stylish Privacy Wall

Use the Trex Find a Builder  location on the Trex.com website to find a list of TrexPro® deck builders and contractors in your area who build Trex decks. Or do you just want a small, backyard sanctuary to soak up some sun? How you plan to use your deck will play a role in determining its size and scale.

The first step is to figure out how you want to use your space, what it should look like, and what features you want to include in the design. Choose colors, get a quote and design your next outdoor space with our easy-to-use online tools. The same principles stand as creating a deck with a pool – the deck is a great place to dry off and helps avoid a muddy lawn. In fact, hot tubs are a great way to enjoy your deck in the colder months.

Choose Modern Comfort

When a railing is required by code, but you want to keep an open and airy view, try Signature Rod Rail in Charcoal Black. This contemporary stunner simply disappears into the Utah Mountain range, helped by our minimalist aluminum collection. Mesh infills lend an industrial touch to this bronze aluminum railing, letting the California coast sparkle. The powder-coated panels are made from six-gauge steel making it super durable and resistant to corrosion. Trex Signature® glass railings offer the ideal pairing of safety and scenery for homes with breathtaking views like this Evergreen, Colorado home.

Download your deck plan.

trex deck design ideas

Decking, as you can see in this lovely example, is an excellent solution for this type of area. Just make sure there are plenty of comfortable couches, possibly an outside rug, and some low, glowing lighting to create a pleasant atmosphere. The choice of a neutral tone is soothing and thoughtful, and the woven elements on the rug and chairs are particularly appealing. Small additions like a potted cactus and an attractive candlestick offer a nice personal touch. How about something like this if you like a more minimalist look?

10 Top Deck Trends of Summer 2023, According to Experts - Better Homes & Gardens

10 Top Deck Trends of Summer 2023, According to Experts.

Posted: Tue, 01 Aug 2023 07:00:00 GMT [source]

What different types of composite decking are there?

With a variety of composite or aluminum options and multiple infills and colors, railing lets your personal style shine. Unlike wood, composite decking comes in a variety of rich colors that allow you to customize your space. The idea of a deck brings to mind wood boards and railings and a rocking chair or two. In reality, however, a deck can be whatever you want it to be. Your deck should reflect your personal style just like your home does, so don’t let tradition restrain you!

Planters, a gas fire pit, and plenty of glowy lighting finish the scene perfectly. From illuminated levels to stunning walls, the best composite decking can be used in all sorts of ways in your plot. Made from plastic and wood fibers, this landscaping material is often regarded as the superior option for decking when compared to all-timber designs. Well, for starters, it isn't prone to rotting over time, unlike wood, meaning it will last longer. What's more, there's no need for the annual weatherproofing treatment that timber calls for. It also tends to be grippier underfoot, so is practical in terms of safety, too.

You can build your own gate or use premade models such as the Trex aluminium deck gate, designed with strength, durability and easy care. Here, this small screened-in porch provides the ideal place to sit a spell and watch the Spanish Moss waft in the lowcountry air. You don’t need a lot of bells and whistles to dress up your outdoor space. A couple of attractive Adirondack chairs and a few plants make for a comfortable spot that will soon become your favourite room in the house. Challenge the traditional with a deck design that transcends the ordinary.

This stunning deck design differentiates the two tiers by using a different color for each level. The Trex® AR Visualizer lets you compare colors, railings and deck sizes in real time with your backyard. Outdoor deck furniture ideas can be just as fun as decorating inside, so take some time to decide how to dress your deck or patio. Think through the activities you plan to enjoy on your deck and then design accordingly.

You can use a sail canopy or beams to suit your needs and taste. However, a new deck made of natural wood will cost more in the long run. The wood will eventually rot, even under normal weather conditions. Featured in our How To Resurface a Wood Deck with Trex Transcend® Composite Decking Guide, this DIY ground-level deck brings contemporary style to this Georgian home. Scroll to see this stunning southern space from every angle.

Decking ideas for small spaces can transform an awkwardly shaped or cramped yard into a stylish haven. In fact, creating multiple areas in your yard using a deck and maximizing storage possibilities can make a small space seem much bigger. Outdoor kitchens can be anything from a covered patio grilling area to a full food prep area with counters and running water, a pizza oven, and a ten-seater dining table! A backyard kitchen means you can take parties outside, eat a la carte the first perfect day of the year, or experiment with smoking food without smoking the whole house. Yes, our free deck AR visualizer tool allows you to virtually “build” a deck in your backyard space. A little decked area may have the same impression as a larger decked area, and installing a deck is a simple way of creating a level area in a tiny garden.

If your deck is positioned closer to ground level, you have more design options. The rail becomes optional so you can create a barrier using planter boxes and a bench. Simply select the dimensions that best suit your space and immerse yourself in the complete design experience with the Trex® Deck Designer. Compare materials, explore colors and more to make it uniquely yours. Consider expanding the roof structure to make a covered area for your decking if you’re building a new addition. For a smart and coherent aesthetic, match the decking color to the wood used on the roof’s underside.

Student Affairs

dawg house

On “Champagne Moments,” Ross plays the ghost of Christmas past, present, and future by bringing up old rumors of ghostwriting, making the internet question whether or not Drake got a nose job, and everything in between. And then of course, there’s the cover artwork, which looks like a photoshopped photo of Drake as a white man, but is, in fact, a real photograph. Good old-fashioned shit-talking is the foundation of any good diss track, and Rick Ross is a hall-of-famer when it comes to that. In addition to traditional wooden plank and heavy-duty plastic dog houses, some dog houses are made from engineered wood, stucco, and even recycled goods.

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Listen to our Spotify playlist to stream songs by our featured artists. One of the most lovable things about dogs is their attachment to you, their pet parent. Although you, of course, adore spending time with your four-legged friend, there are times when you might want your space — for instance, when it's time to go to sleep.

dawg house

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While dogs can’t appreciate family photos hanging on the walls of their home, that doesn’t mean you should leave your dog’s house empty. Putting down a layer of cedar shavings will cut down on fleas and other nasty pests, and comfortable bedding will help keep your dog cozy. During warmer months, you can help your dog stay cool by placing ice packs inside the dog house — just make sure you’re using pet-friendly materials. However, if you live in a colder climate where frigid winters are the norm and the summers are mild, a smaller dog house might be a better option. Smaller spaces retain more heat during the cold winter months, while providing adequate shade from the hot, summer sun may be enough to keep your dog cool when it’s hot out. As long as your dog has enough room to enter and turn around comfortably, then they have plenty of space inside.

University Village/Health Sciences Campus Contracts End For Non-Returning Students

Drake is in the middle of an all-out war against Kendrick Lamar (and half the rap game) right now, and diss songs are getting lobbed back and forth. Dog houses are fairly simple and budget-friendly projects and can be usually be completed by someone with just basic building skills. They'll take anywhere from half a day to a few days to complete and can easily be done for under $100. Welcome to "Around the DawgHouse" where we update you multiple times each week on the latest news and information from the different sports.

Danbury's Dawg House Daycare and Boarding business completes expansion: 'now the fun starts' - Danbury News Times

Danbury's Dawg House Daycare and Boarding business completes expansion: 'now the fun starts'.

Posted: Mon, 25 Sep 2023 07:00:00 GMT [source]

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Guests can also experience Mouse House, a dining truck serving specialty grilled cheeses within Dawg House. Placing a high-quality dog bed in your dog’s house will keep them comfortable regardless of the weather. Thick, flannel beds are a great option during the winter months, and breathable foam is a good choice as the temperature rises. Some dog beds even have a layer of cooling gel to ensure your pup doesn’t overheat in hot weather.

Let your unique dog house ideas come to fruition so your furry friend can relax in style. That way, he or she can chill in a fun, interesting space that will make your backyard infinitely more stylish — and keep your dog happy and comfortable in their home no matter the season. Yes, J. Cole loses points for apologizing for his diss at Kendrick Lamar and taking “7 Minute Drill” off of streaming. But even though Cole’s heart was never in the fight in the first place, his response to Kendrick’s “Like That” verse still out-paces some of the AI raps and self-indulging remixes that have followed it. There have already been half a dozen diss songs in the rap war between Drake, Kendrick Lamar, and more. We’re the only spot on the Las Vegas Strip where you’ll find a variety of live music and dancing with no cover charge!

Future & Metro Boomin f/ Kendrick Lamar, “Like That”

Around The DawgHouse is also a daily feature on DawgNation Daily. Students should plan to leave the residence halls May 8, 2024 at 12 p.m. "We have done our best to get off of the Borough water system but you still may have discolored water for a period of time," said Gibney in the post. The massive building, which was once the historic Stewartstown Furniture Factory, became an auto parts supply warehouse. A massive, six-alarm inferno engulfed a former furniture factory early Saturday morning in southern York County. The Ultimate Guide to Keeping Animals Happy & Healthy.PawTracks brings inspiration, tips, the best products on earth to ensure our readers and their pets are happy and healthy.

Rappers like Rick Ross and Ye have answered the call, while Drake has been fighting back with his own responses (and AI?) to even the score. As we wait for more shots to land in the near future, here is a ranking of all of the direct diss tracks (not counting some of the more subliminal verses on We Still Don’t Like You) that have come out of this rap war so far. Before using these free dog house plans to build your dog's dream home, make sure that it will be the right fit for the size of your full-grown dog. Some of these plans can even be customized to fit any size of dog, so be sure to look for instructions within the plans for that. These 14 free DIY dog house plans will make sure that your dog has a safe haven from the weather and you can take pride that you built it just for them.

Simple A-Frame Dog House Plan

Are you looking for a dog house that will hold up to rainy weather without leaking? Plastic dog houses are lightweight, reasonably priced, and they come in a wide variety of unique designs. You can find plastic dog houses shaped like castles, miniature homes, and barns. Some dog houses even have built-in food and water bowls, so your dog won’t have to leave the comfort of their home for long to have a bite to eat. A good dog house will provide enough space for your dog to turn around comfortably. If you live in a warm, sunny climate with mild to moderate winters, you should ensure your dog has plenty of space inside of their home.

Kendrick rang the bell for the whole battle with his appearance on “Like That” and there still hasn’t been a moment that’s topped it (yet). With one explosive verse that shook up the entire rap landscape, Kendrick finally put an end to all of the pump-faking he and Drake had been engaging in since he last pushed the red button on “Control” a decade ago. What’s most impressive about “Like That,” though, beyond its sheer impact, is how effective Kendrick is in so few bars. He wastes no time to refute the Big 3 label, shit on Drake’s affinity for Michael Jackson with a clever bar about Prince, and make it clear that he wants all the smoke. Metro Boomin finding a way to say “fuck you” to Drake through the club-friendly production also helps make the case for “Like That,” a song that’s been sitting at No. 1 on the Billboard Hot 100 chart for three weeks. Drake has long been praised for his ability to diss rivals on hit songs that they have to hear in the club, so you know he’s seething now that someone did it to him.

Chances are good you’ll want to show off a unique, stylish dog house, but you should always keep your dog’s comfort in mind while doing so. Placing your dog house in the shade during the summer will help keep your dog cool, while moving it to the sunniest location in your yard will ensure maximum warmth during the winter months. If your dog is prone to overheating — or you live in a hot climate — avoid heavier materials that trap in heat. A roof made from engineered wood is a better fit than a shingled roof, as it won’t retain as much heat as dense shingles.

According to HOMAGE, this is a limited release and they don’t expect them to last long. Click here to purchase one, and let us know which one you decided to get. Even if it’s not for you, they would make an awesome birthday or early Christmas gift to stock up on for any family, friend, or colleague. Enjoy a variety of libations from one of our eclectic bars and lounges. This website is using a security service to protect itself from online attacks.

Kendrick managed to trigger an entire rap war off his first hand, so there’s no telling what else has up his sleeve. During the winter months, dog houses keep your dog warm and help to prevent hypothermia. Whatever the season, making sure your pooch has access to a comfortable dog house is important to their health and happiness. Rick Ross gets points in this rap war just for pulling an extremely Rick Ross kind of a move and responding to Drake’s “Push Ups” within a few hours of the track “leaking” online.

There are several actions that could trigger this block including submitting a certain word or phrase, a SQL command or malformed data. Firefighters set up tanker shuttles to attempt to ease the impact on the municipal water supply. As dawn broke Saturday morning, flames and smoke continued to billow out of the hollowed out walls of the massive structure, with four ladder trucks pouring water onto the wreckage. DETROIT, Mich. — University of Georgia TE Brock Bowers is the first Bulldog to be drafted in the 2024 NFL Draft. Physically present in AZ/CO/CT/IL/IN/IA/KS/KY/LA(select parishes)/MA/MD/ME/MI/NC/NH/NJ/NY/OH/OR/PA/TN/VA/VT/WV/WY only.

Free and Customizable Postcard Templates Fotor Online Graphic Designer

postcard design template

No matter how many templates are selected and how many design tasks are created. No matter how many images and design elements are used or uploaded in the design. The beauty lies in the details – tailor the layout of your postcard to your liking, choosing from an array of design options that suit your personality or the mood you want to convey.

How to write a postcard?

Our gallery offers an array of customizable online postcard design templates created by talented designers. You can easily search for the perfect postcard design template by theme, color, industry and more. Each postcard design comes in a variety of shapes, including ovals, rounded corners and fancy edges. Choose a style that suits your needs, add in your own information, and you’re set. And with PsPrint’s high-quality postcard printing, you know you’re getting quality you can afford.

templates

You can just as easily download a print-ready PDF and send it to your local print shop or another online printing site. You can even download a full-bleed file that prints great on any professional printing equipment. First and foremost, everything you write on a postcard should go on the back.

Tasteful designs and elements

postcard design template

If you prefer a more personal approach, have your postcard printed with Kittl and hand-deliver it to your loved ones, or send it through the mail. Pixlr's Postcard Maker provides a selection of customizable templates that allow you to create unique postcards. Utilize the straightforward drag-and-drop interface to incorporate your personal photos, text, and graphics, ensuring your postcards are visually captivating. When designed well and targeted to the right people, postcards are a very effective means of marketing any local business.

Beautiful postcard templates

Stick the stamp on the top right corner of your postcard, which is the standard placement for stamps. You can buy a stamp at the post office, bank, gas station, supermarket, etc. No need to find design materials across platforms, and worry about any copyright issues.

Postcards have many uses, whether for personal or professional communication, and can be a great way to keep in touch with customers and friends. Take it old school and dig out that old address book to start sending your own postcards. A postcard is a rectangular piece of thick paper or cardstock that is sent via mail without an envelope. These typically have a beautiful photo or design on one side and lines for mailing address and a quick note on the other, but one-sided postcards can also be created.

Browser more designs

Signed, sealed, delivered — PsPrint's postcard design templates are yours. If you need quick postcard printing, then you’ve landed at the right place. In PsPrint’s easy-to-personalize postcard design template gallery, you can shop for a postcard design template and then customize it yourself. Your postcard will be a one-of-a-kind design that will be sure to stand out.

Choose the postcard collection and select your preferred postcard template. Open the template in Pixlr E to begin customizing your postcard. Personalize the template with your own photos or browse our stock photo library to find the perfect fit.

Related templates

Click to remove image backgrounds, perfect for product photos, headshots, or transparent PNGs. You can visit the user center of Drawtify’s online post card maker at any time to choose any saved design. Drawtify’s free post card maker runs completely online and is constantly updated, so you don’t need to download or install any other software on your computer. Great tools and overall great work inspiration ready to use. All-in-one photo editor for easy editing and better design.

University of Connecticut University Communications University Design Services - University of Connecticut

University of Connecticut University Communications University Design Services.

Posted: Sun, 24 Jul 2022 17:51:50 GMT [source]

Our postcards are printed on firm, durable cardstock with high-gloss UV finish on one or both sides. This premium paper stands up well to shipping so that your recipients will get a high-quality mailing that reflects well on your brand. Both of these standard sizes are designed for bulk printing and delivery to a single address (like your home or office).

Stay in touch with those who matter most by quickly putting together a beautiful and thoughtful postcard design. A postcard is a card with pictures and text that can be sent directly without an envelope. Its form is simple, but only charming postcards can attract people’s attention. Therefore, by using a powerful and free postcard maker, creating beautiful customized postcards online is your best choice.

At Edit.org, we publish a new and modern collection of postcard templates. With simple clicks and without using Photoshop, you will be able to create high quality printable postcards in seconds. Change the color, include your store logo and contact details and change the texts if required.

Postcards are a crucial marketing tool and can be used to attract new clients or give a friendly reminder of services to existing ones. You can personalize every element, including text, images, colors, and more, to align with your unique style or branding. Choose one of our premade customizable postcard templates to help you create custom postcards for your audience.

Your CTA could be an invitation to visit your new location, participate in a sale, utilize valuable coupons, join a rewards program, attend an event, or call for a free consultation. Browse our catalog to find a postcard template that meets your needs. Gather together your high-quality images, original content, and an understanding of your company’s branding strategy, then open your chosen template in our online editor. Share your life and adventures with family and friends by creating and sharing your own custom postcards. Make postcards that allow your photos to shine, print them out and mail them to everyone you know.

Monday, April 29, 2024

AI designs new drugs based on protein structures

computer-aided drug design

For any protein with a known three-dimensional shape, the algorithm generates the blueprints for potential drug molecules that increase or inhibit the activity of the protein. Once lead compounds are identified from experiments, LBDD methods can be utilized to start to develop an SAR or find more hit compounds. It can search for compounds that are chemically or physiochemically similar to the input compound, as described below. This approach may also be used as lead validation, as a compound that has multiple analogs with biological activity from which SAR can be developed is appropriate for further studies (88). Understanding the atomic-detailed mechanism behind the antibiotics resistance helps to reveal limitations in current antibiotics and shed light on the design of new drugs.

Professional development

computer-aided drug design

Availability of the multilayer on-demand chemical space extensions (for example, supported by MADE building blocks47) can also greatly streamline the next steps in lead optimization through ‘virtual MedChem’, thus reducing extensive custom synthesis. The limited size and diversity of screening libraries have long been a bottleneck for detection of novel potent ligands and for the whole process of drug discovery. An average ‘affordable’ high-throughput screening (HTS) campaign29 uses screening libraries of about 50,000–500,000 compounds and is expected to yield only a few true hits after secondary validation.

My comments on ICMJE Data-sharing proposal

The recently developed virtual synthon hierarchical enumeration screening (V-SYNTHES)26 technology applies fragment-based design to on-demand chemical spaces, thus avoiding the challenges of custom synthesis (Fig. 3). Starting with the catalogue of REAL Space reactions and building blocks (synthons), V-SYNTHES first prepares a minimal library of representative chemical fragments by fully enumerating synthons at one of the attachment points, capping the other position (or positions) with a methyl or phenyl group. Docking-based screening then allows selection of the top-scoring fragments (for example, the top 0.1%) that are predicted to bind well into the target pocket. This is repeated for a second position (and then third and fourth positions, if available), and the resulting focused libraries are screened at each iteration against the target pocket.

4. Site identification using SILCS-Hotspots

Several approaches have been developed recently to push the library size limits in HTS, including combinatorial chemistry and large-scale pooling of the compounds for parallel assays. For example, affinity-selection mass spectrometry techniques can be applied to identify binders directly in pools of thousands of compounds33 without the need for labelling. DNA-encoded libraries (DELs) and cost-effective approaches to generate and screen them have also been developed34, making it possible to work with as many as approximately 1010 compounds in a single test tube35. These methods have their own limitations; as DELs are created by tagging ligands with unique DNA sequences through a linker, DNA conjugation limits the chemistries possible for the combinatorial assembly of the library. Screening of DELs may also yield a large number of false negatives by blocking important moieties for binding and, more importantly, false positives by nonspecific binding of DNA labels, so expensive off-DNA resynthesis of hit compounds is needed for their validation. To avoid this resynthesis, it has been suggested to use ML modes trained on DEL results for each target to predict drug-like ligands from on-demand chemical spaces, as described in ref. 36.

Types of CADD

Contributing to this is the steady rise of antibiotics drug resistance leading to the need for new antibiotics (1, 2). Toward the design of new antibiotics, computer-aided drug design (CADD) can be combined with wet-lab techniques to elucidate the mechanism of drug resistance, to search for new antibiotic targets and to design novel antibiotics for both known and new targets. Notably CADD methods can produce an atomic level structure-activity relationship (SAR) used to facilitate the drug design process thereby minimizing time and costs (3, 4).

The transformational role of GPU computing and deep learning in drug discovery

The approach uses a pre-computed MD simulation of the hit compound-target complex from which the free energy difference due to small, single non-hydrogen atom modifications (e.g. aromatic –H to –Cl or –OH) can be rapidly evaluated (103). This is in contrast to the need for many simulations in which the chemical modification is introduced in standard FEP methods (102). SSFEP has the ability to give rapid predictions of binding affinity changes related to modifications and, thus, is quite useful for lead optimization (104). Despite the fact that numerous antibiotic drugs are available and have been routinely used for a much longer time than most other drugs, the fight between humans and the surrounding bacteria responsible for infections are ongoing and will be so for the foreseeable future.

Currently, the largest commercial space, Enamine REAL Space, is an extension to the REAL database that maintains the same synthetic speed, rate and cost guarantees, covering more than 170 reactions and more than 137,000 building blocks (Box 1). Most of these reactions are two-component or three-component, but more four-component or even five-component reactions are being explored, enabling higher-order combinatorics. This space can be easily expanded to 1015 compounds based on available reactions and extended building block sets, for example, 680 million of make on demand (MADE) building blocks47, although synthesis of such compounds involves more steps and is more expensive. A large number of trials are being conducted to identify binding modes of ligands and selection of the most energetically favored poses. In order to achieve this, molecular docking tools are used to generate a set of different ligand binding poses and a scoring function is used to estimate the binding affinities of generated poses to identify the best binding mode. The energy change caused by ligand/receptor complex formation, is given by the Gibbs free energy (ΔG) and the binding constant (Kd) [49, 50].

The most reliable and accurate region in the 3D structure in the protein-ligand complex is the analysis and prediction of the region in a protein where ligand can occupy its best pose. Several cavity prediction tools, such as Castro, Q-site Finder, and COACH, can provide the probable location of the binding site in a protein. The evolutionary-based approach takes the information on all related proteins and shows nearly the same binding site. Geometry-based approaches are based on the features, such as shape, hydrophobic surface, and charged surface residues, whereas an energy-based approach uses a probe to identify the favorable binding regions on a protein.

This included studies on the mechanism behind antibiotic resistance that may help to guide the design of new antibiotic drugs to overcome such resistance. Al. studied the mechanism of a S222T mutation induced resistance of Deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) to fosmidomycin using molecular dynamics (MD) simulations (5). The MD simulations revealed the structural and energetic basis of the single mutation that induced resistance shedding light on the development of a new antibiotic compounds targeting DXR.

Breakthroughs in Computer Aided Drug Design - Drug Discovery News

Breakthroughs in Computer Aided Drug Design.

Posted: Mon, 24 Jul 2023 16:26:38 GMT [source]

The position and motion of every atom of the system are captured at every point in time, which is quite tough using any experimental technique. MD simulations have been extensively used in the structure-based drug discovery process as this technique helps to unravel many atomistic details such as binding, unbinding, and conformational changes in the receptor at a fine resolution which normally cannot be obtained from experimental studies [59, 60]. Further, using MD simulation it is possible to explore the dynamics of receptor-ligand interactions (association and dissociation) and quantify the thermodynamics, kinetics, and free energy landscape [61]. Virtual screening (VS) is a computational technique used for screening large datasets of molecules, and has been successfully used to complement High Throughput Screening (HTS) for drug discovery [8, 20, 21]. The major aim of VS is to enable the rapid, cost-effective evaluation of huge virtual compound databases to screen for effective leads for synthesis and further study [22]. Virtual database screening can be applied to screen large libraries of compounds using various computational approaches to identify those entities likely to bind to a molecular target of interest [23, 24].

SILCS-MC then involves simply assigning the GFE value for the appropriate FragMap type to each atom in the molecule and summing those values to get the LGFE score. MC conformational sampling is then performed to allow the orientation and conformation of the ligands to relax in the field of the GFE FragMaps. This allows for SILCS-MC docking to be performed in a highly computationally efficient fashion while achieving a level of accuracy similar to highly expensive FEP methods (109).

Below, we discuss some emerging technologies and how they can best fit into the overall DDD pipeline to take full advantage of growing on-demand chemical spaces. HDAC6 is a member of the class IIb Histone deacetylases (HDACs) family and is usually found in cytosol in association with non-histone proteins [77, 78]. The implementation of CADD has been reported to result in the design of a potential inhibitor of this enzyme. In one study conducted by Goracci et al., a virtual screening approach was used to identify potential inhibitors for HDAC6, and these were then subjected to in vitro testing.

At the final step, the top approximately 50,000 full compounds from REAL Space are docked with more elaborate and accurate docking parameters or methods, and the top-ranking candidates are filtered for novelty, diversity and variety of desired drug-like properties. Another important part of the algorithm is the evaluation of the fragment-binding pose in the target, which prioritizes those hits with minimal caps pointed into a region of the pocket where the fragment has space to grow. Like SARS and MERS, the genome of SARS-CoV-2 encodes sixteen nonstructural proteins (nsps) such as main protease (Mpro), papain-like protease, RNA-dependent RNA polymerase (RdRp), helicase etc., four structural proteins (envelope, membrane, spike, and nucleocapsid), and other accessory proteins.

Any computational tool based on pre-defined algorithms and scripts has its limitations, and the computational tools/methods used in CADD, such as, molecular docking, virtual screening, QSAR, pharmacophore modeling, and molecular dynamics, have their own limitations [49, 85-88]. Furthermore, ADME and many toxicity prediction tools are not supported by solid experimental data, and many examples of the failure of these computational approaches can be found in the literature [89, 90]. ML algorithms are not new to the CADD area, but the increasing need for AI in areas such as image recognition and text processing promote powerful novel ML algorithms that can handle vast amount of data (29, 30). The refined graphic processing unit (GPU) architecture (31) and its growing computing power further accelerate the applications of ML, and its adaptations in CADD has erupted in recent years. ML models were trained against the resistance profiles of 14 antibiotics across three urgent pathogens using genome sequences as inputs.

The concept can be referred to as drug reprofiling as uncovering new indications of the either of approved/ failed/ abandoned compounds to put in use for different diseases. For larger system, more advanced MD techniques can be employed to enhance the sampling efficiency such as replica exchange methods. The protocols developed in our lab such as Hamiltonian replica exchange with biasing potentials (107) and replica exchange with concurrent solute scaling and Hamiltonian biasing in one dimension (108) are efficient replica exchange methods for use to enhance the MD efficiency.

One of these is a project with the Children's Hospital Zurich for the treatment of medulloblastomas, the most common malignant brain tumours in children. Moreover, the researchers have published the algorithm and its software so that researchers worldwide can now use them for their own projects. A new computer process developed by chemists at ETH Zurich makes it possible to generate active pharmaceutical ingredients quickly and easily based on a protein's three-​dimensional surface. Dr. Julia Schaletzky is the Founder of the UCB Drug Discovery Center, the Executive Director of the Center for Emerging and Neglected Diseases, as well as of the Immunotherapy and Vaccine Research Initiative at UC Berkeley. An expert in drug discovery and preclinical development, Dr. Schaletzky has more than 10 years industry experience, contributing to the development of first-in-class therapies for heart failure and neurodegenerative diseases. Melanie Cocco has a PhD in Organic Chemistry from Penn State and was an NIH postdoctoral fellow at Yale in the Department of Biophysics and Biochemistry.

Sunday, April 28, 2024

Buying a house? How one pair got their California dream home Los Angeles Times

way of the house husband

Tran left the Nashville job and came back to Southern California. The Streamable helps you find the best way to stream anything. Follow our daily streaming news, and in-depth reviews on streaming services & devices, and use our tools to find where your favorite content is streaming.

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You will need this to get legally married in Los Angeles county. We did the appraisal and inspection the same day. The one in La Puente, my husband really wanted.

Despite ‘Heartbreak,’ Sophia Bush’s Fertility Journey Was the ‘Most Clarifying Experience’ of Her Life

My husband, who is upstate visiting his mother until Saturday, has next to no cell service so I haven't been able to talk to him about any of this other than saying that the email must have been a 'mix up'. My friend called and got his apartment number from the maintenance man. Both of us went over to the apartment and my friend knocked. A girl answered but didn't answer the door, just the bell camera.

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With temperatures in the low to mid-70s and fewer crowds, spring is a comfortable season for walking and visiting outdoor attractions. There’s rarely any precipitation in LA during the springtime, making it ideal for outdoor weddings. Also, hotel rates are likely to have discounts during this time, which is great for traveling guests. City Hall weddings are increasingly popular for affordable, same-day ceremonies. The City Hall is easy to book, LGBTQIA supportive, and can serve as a neutral ground for couples with different religious backgrounds. County RR/CC offers to conduct civil weddings virtually via online appointments.

Gokushufudou

It was an email from an apartment complex that they were going to be temporarily closing down the hot water for repairs, sent from one of those automatic senders that you can’t reply to. With this guide, you and your partner have everything you need to plan the perfect LA wedding. Be sure to check out more expert advice for additional tips and resources on all things wedding. From destination wedding checklists to invites, Zola has everything you need all in one place.

My Manga Shelf Presents: The Way of the Househusband 1 - The Mary Sue

My Manga Shelf Presents: The Way of the Househusband 1.

Posted: Thu, 01 Apr 2021 07:00:00 GMT [source]

The bank or the escrow company needed the money by a certain time, and the money came in later, so we had to wait an additional one or two days to close because of that, which we weren’t aware of. We realized, OK, well, we have actually a pretty good budget to work with. Buying a house in California has become increasingly hard. The pandemic pushed the market into overdrive as people scrambled for more space.

way of the house husband

I haven't slept so I hope this makes sense. Call them, explain you have a delivery for Mr. OP but the Unit # is missing & you’re under a deadline to deliver, as it’s perishable. There was no unit number on the email but the complex is about 15 minutes away from our house so I went and I drove by. Which I guess might be a little crazy, I know. I didn’t see anything (not like I knew what to expect?) It’s a group of buildings. We’ve got wedding planning advice on everything from save the dates to wedding cakes.

way of the house husband

Virtual civil weddings cost $35 in addition to license fees. The L.A County RR/CC distributes marriage licenses. Currently, during the COVID-19 pandemic, you can apply for your marriage license online through the county’s website. Once reopened to the public, you and your partner can apply for a marriage license at one of its seven branch office locations. "OP should go straight to a lawyer and not bother talking to their partner about it first" might be the most stereotypically internet take of all time. Being in touch with a lawyer is not better than confronting him first.

Open houses

Read the full story, Reddit’s response, and our ultimate takeaways ahead. After disappearing from the underworld, the legendary yakuza known as the "Immortal Dragon" resurfaces — as a fiercely devoted stay-at-home husband. I can also understand she may be under shock with how everything played out.

They had been renting a house in the San Gabriel Valley and were hoping to land somewhere between there and the Long Beach area, where her parents live. “Messy” doesn’t even begin to cut it for that situation, which is what one woman on Reddit is finding out right now. She agreed to stay with her husband after an affair and an affair baby came to light — but now, somehow, it’s all getting even more complicated. With her husband asking that they take in the affair child (now older), the woman (aka our OP, or the author of the post) responded in a way that has Reddit’s Am I the Asshole?

The Way of the House Husband: Who is Tatsu - GameRant

The Way of the House Husband: Who is Tatsu.

Posted: Fri, 29 Apr 2022 07:00:00 GMT [source]

This is also a season when you can find good flight and hotel deals, which can especially come in handy to catch famous award shows in LA at this time, such as the Grammys. Fall has cooler temperatures in the high-70s and is a great time to find flight and hotel deals when planned. If you prefer to avoid the peak tourist season, a fall wedding might be your best option.

Otherwise he might talk her into thinking you were just a jealous future ex wife stalking his new girlfriend or something. In sugar dating it's pretty common for the allowance and help with rent/bills etc to start pretty early, sometimes after the second date. If he was her sugar daddy then OP might have a financial claim to the marital assets he spent supporting the girlfriend. I am guessing the girlfriend messaged him which is why he knew why you were there. Be sure to login to your bank accounts and if you feel it is necessary take a screenshot and withdrawal half of it into a new account just under your name. I’m not going to get into the exact details of it.

That kind of confrontation is not just "are you having an affair?", there's plenty of other answers OP deserves also. Especially since the first answer really could be anything from "yes, that's my other wife" to "no, that's the daughter my HS gf hid from me for 25 years" and anything in between. Currently, Los Angeles County can only have small private gatherings with a maximum of 15 individuals. Private gatherings must be outdoors with all guests wearing masks and maintaining a 6-foot-distance. If you, your partner, and all other wedding guests are fully vaccinated by your wedding date, you’re free to have an indoor wedding without restrictions.

It was a one-bath, three-bedroom but had a converted garage. There were 20 people in line to see that particular home, and we had heard that particular house had 36 offers. But they accepted an offer for $100,000 over asking. Tran and her husband, John, 30, started looking to buy a place last year to make space to grow their family.

Mickey's House at Disneyland: Things You Need to Know

mickey mouse club house

Mickey Mouse Clubhouse is an American animated interactive television series for preschoolers. Produced by Disney Television Animation, the series was created by Disney veteran Bobs Gannaway. The series originally aired 125 episodes from May 5, 2006, to November 6, 2016, on the Disney Channel's preschool block, Playhouse Disney (later known as Disney Junior), making it the longest-running original series to air on the block. Mickey entertains a new generation of preschoolers for the first time by inviting them to join him and his favorite friends (Goofy, Donald, Minnie, Daisy & Pluto) for a date at the Clubhouse.

The Picture Puzzle

For example, in "Mickey's Silly Problem", when the "Silly switch" turned on, Mickey spoke in rhymes for half of the episode. At the beginning of certain episodes, the Picture Puzzle will light up and play a song, and Mickey and the viewer will have to unscramble a four-piece puzzle to reveal a hidden picture; the picture will be whatever relates to the theme of the episode. Pushing a red button at the center of the unit sets the Picture Puzzle in motion.

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A successor to this series, Mickey Mouse Mixed-Up Adventures, originally Mickey and the Roadster Racers, debuted on January 15, 2017. It was then succeeded by Mickey Mouse Funhouse, which debuted on August 20, 2021. However, a special episode of this series premiered on July 16, 2021 before the series debut. And with ESPN+, you can stream live sports, thousands of live events, top leagues and tournaments, ESPN+ Originals, and the complete 30 for 30 Library. Plus, get exclusive access to premium articles, fantasy tools, and archives. The Disney+ app is available on mobile devices, web browsers, game consoles, set-top boxes, and smart TVs.

Running time

Visit the Disney+ Help Center to learn more about Disney+ through Spectrum support. Disney Bundle plans include subscriptions to either Disney+ and Hulu, or Disney+, Hulu, and ESPN+, at discounted prices, as compared to the retail price of each subscription when purchased separately. All of these and more now streaming on Disney+, Hulu, and ESPN+ with the Disney Bundle. After the show ended in 2016, it was succeeded by Mickey and the Roadster Racers (later renamed Mickey Mouse Mixed-Up Adventures), which ran from 2017 to 2021, and Mickey Mouse Funhouse, which started in 2021.

‘Mickey Mouse Clubhouse’ Revival Leads Disney Junior Slate; Taye Diggs To Voice King Triton With Amber Riley As Ursula In ‘Ariel’ Animated Series - Deadline

‘Mickey Mouse Clubhouse’ Revival Leads Disney Junior Slate; Taye Diggs To Voice King Triton With Amber Riley As Ursula In ‘Ariel’ Animated Series.

Posted: Fri, 18 Aug 2023 07:00:00 GMT [source]

Mickey Mouse, walking up a dotted path, greets the viewers and invites them to a playdate at the Clubhouse. He directs viewers to a plot of land where the Clubhouse is, but it's nowhere to be seen. He then remembers and reminds viewers that the Clubhouse can only be summoned using the "magic words" "Meeska, Mooska, Mickey Mouse!" Once said, the Clubhouse forms itself and Mickey and his friends arrive to hang out and play together while the theme song plays.

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mickey mouse club house

You can walk through his living room, den, laundry room and back yard and greet him in his dressing room in the Movie Barn. You can watch a classic cartoon on the television, check out Mickey's collectibles which include a special photo of Mickey with his pal Walt Disney, and don't miss the oversized vegetables in the garden. The 'Mickeyologist' home in Los Angeles could be called the 'Mouse House.' It's filled with games, watched, toys, dolls, even an original Walt Disney business card. When ABC7's George Pennacchio asked Shine, "How many Mickey items do you think you've collected?" Shine had no idea, but he did share a desire to one day share all of his collectibles in some for or fashion. As he put it, "It's better when this kind of Mickey magic and joy is shared." In addition to the Main Living Area, Otherwise known as the “Anywhere Area”, there are other rooms located within the Clubhouse that can be accessed by merely pulling the Anywhere Lever.

Britney Spears settles legal dispute with estranged father

It was revealed that Mickey and the gang think of the Handy Helpers as helpful friends and not servants. One Handy Helper is usually seen opening the front door for The Sensational Six and their friends. In one episode, the Handy Helpers begin to act crazy and stop working, and Mickey and the gang decide to help out, stating that the Handy Helpers are their friends. It was also revealed that the inner workings of the Handy Helpers come from the Handy Dandy Machine located in the basement underneath the Clubhouse which can be accessed by a down slide. The Mousekedoer is a special machine that runs on a special energy source called "Liquid Light" and is the main power source for Toodles, as revealed in "Mickey's Mousekedoer Adventure". Whenever the Sensational Six are about to set off on a fun adventure or important mission, the Mousekedoer provides them with special Mouseketools that will help them on their mission/adventure.

Mickey Mouse Clubhouse Chair Sale Online - Atlanta Progressive News

Mickey Mouse Clubhouse Chair Sale Online.

Posted: Thu, 25 Apr 2024 12:22:36 GMT [source]

Mickey Mouse Clubhouse

The Mousekedoer usually provides between 3-5 Mouseketools per adventure/mission. On occasion, the Mousekedoer will provide Mouseketools unique for the adventure. For instance, in "Goofy's Thinking Cap," the Mousekedoer provided 4 Mouseke-Think-About-It Tools instead of the usual Mouseketools to help them think up any kind of tool they need. Another example was in "Mickey's Mystery" where each Mouseketool was hidden behind a pictogram to describe the Mouseketool needed for the mission. These tools are transferred into Toodles who would later distribute the tools to the gang when called upon. Besides providing the Mouseketools, the Mousekedoer is also known for many other things.

If the Liquid Light isn't flowing back to the Mousekecore and the Mousekecore isn't started up in time, the Mousekedoer would stop working all together and, in turn, Toodles will shut down permanently. The size of the hands' gloves can also vary depending on the task, from the same size as the famous characters to giant size. In some episodes The Handy Helpers held Mickey or his friends open palm. Usually the Handy Helpers’ gloves are much bigger than the Sensational Six’s hands.

Each visit sees at least one character get into an issue or scenario that must be solved quickly. Mickey could also use the "Picture Puzzle" device to reveal an image that relates to the episode's topic, usually being accompanied by its own song. One of the tools is a "Mystery Mouseketool", which is a surprise tool represented by a question mark that isn't revealed until later in the episode. Toodles lays himself onto the Mousekedoer to download the tools that have been shown on the machine's screen and prepare for Mickey and the gang to use the tools. The episode's main plot then plays as Mickey and his friends search for the solution.

When ready to pick a Mouseketool, the gang shouts "Oh, Toodles!" to call Toodles, who pops up from where he is hiding and presents the set on-screen so the viewer can pick which tool Mickey and his friends need for the current situation, which usually works flawlessly. Mickey then directs his friends back to the Clubhouse to perform the Hot Dog Dance while the person with their issue fixed thanks viewers for their help and Toodles returns to his spot on the Mousekedoer, which spins around to the outside to allow everyone to leave. The Clubhouse then disappears as Mickey thanks viewers for their visit. The program was initially announced on March 1, 2005, by Gary Marsh, who is the Executive Vice President of Original Programming and Production for The Walt Disney Company. The characters debuted in CG form in 2003 at the Magic Kingdom attraction Mickey's PhilharMagic, then in the 2004 home video Mickey's Twice Upon a Christmas.

Another one is a "Mouseke-Think-About-It Tool" represented by a silhouette of Mickey's head with rotating gears, in which characters must think of what to use before telling the Tool "Mouseke-Think-About-It-Tool, we pick the (object)". Once the tools have been shown to Mickey on the Mousekedoer screen, they are quickly downloaded to Toodles, a small, Mickey-head-shaped flying extension of the Mousekedoer. By calling "Oh, Toodles!" Mickey summons him to pop up from where he is hiding and fly up to the screen so the viewer can pick which tool Mickey needs for the current situation.[5][6] Rhymes are used throughout the show.

Mickey Mouse, Minnie Mouse, Donald Duck, Daisy Duck, Goofy and Pluto, the main stars of the show, interact with the viewers and go on problem-solving adventures. The group has a small, Mickey head-shaped flying super computer named Toodles that acts as an extension of the Mousekedoer and helps the gang with the given problems and carries tools that they might need. The series mainly focuses on interacting with the viewer to simulate problem solving. According to Disney, each episode has the characters help children solve a specific age-appropriate problem using basic skills, such as identifying shapes and counting from one to ten. This show is similar to other shows like Sesame Street, Pee-Wee's Playhouse, Dora the Explorer, and Zoobilee Zoo. The series uses "Disney Junior's common 'whole child' curriculum of cognitive, social and creative learning opportunities."

Mickey directly addresses the viewers, inviting them to participate in solving problems. Mickey entertains preschoolers by inviting them to join him and his friends for a date at the Clubhouse. Where the Clubhouse Rocket is kept, situated in the center of the mouse head. Can be accessed via cup car in the main living area or by ladder in the Fanfarea. Should the Liquid Light stop flowing to the Mousekecore (which is basically the heart of the Mousekedoer), the Mousekedoer would start fritzing, give mixed-up Mouseketools, and cause Toodles' screen to glitch.

The garage to the Clubhouse, where various tools and equipment can be found. The door to the garage unlocks by unzipping like a zipper, which can be unlocked with keys or with a secret combination. On August 18, 2023, a revival is revealed to be in production and is set to be released sometime in 2025. To log in, use the email address and password you entered when activating your Disney+ account. Disney+ Basic is available with Spectrum TV Select packages or higher at no additional cost. If you have an eligible Spectrum plan with Charter, you can activate your Disney+ Basic account via the activation link in the Plan Details page of your Spectrum account.

Saturday, April 27, 2024

A storied return: Delta, American Express bring back popular airplane metal credit card design Delta News Hub

back of card design

Most smartphones released after 2017 have built-in NFC scanners that can detect NFC tags. Once picked up by a prospective customer’s phone, an NFC tag can take future customers or clients straight to your website. Here's a great example of a business that played to its strengths. Trick & Treat-- and branded entertainment company -- offers one of the most creative business cards we've ever seen. The design transforms into a tabletop game, which aligns perfectly with Trick & Treat's playful brand. Brazilian designer Matheus Dacosta puts an artistic spin on traditional business cards, adding kaleidoscopic, hand-painted designs to every individual card.

Lucky You set of 2 digital download in navy blue and white.

Chase Freedom Flex Q2 2024 Categories - Bankrate.com

Chase Freedom Flex Q2 2024 Categories.

Posted: Fri, 22 Mar 2024 07:00:00 GMT [source]

Graphic designer Claire Bruining developed these playful business cards for her own personal branding. Splashes of overlapping patterns and colors appear on one side, and Bruining's contact information appears on the reverse in a clean sans serif font. The dark blue text and border adds an unexpected pop to the basic layout. Featuring a botanical illustration of tropical blooms and a clean sans-serif font, these business cards from Aurora certainly make a stylish first impression. The South African studio specializes in whimsical artwork and design, so it's fitting that their business cards reflect their unique skill set. The cards were designed in-house and include gold embossed details.

back of card design

How do you wrap a handmade card?

With a business card made out of pH testing paper, potential customers can dip this card into a pool and see if the pool’s pH balance is in need of service. Not only is the card memorable and interactive, it actually tells customers when it is time to call the business in question. This fitness trainer’s business card shows her customers exactly what the results of her personal training program will be. With a foldable perforated edge, potential customers get to literally “lose the flab” of this business card, giving them a memorable, interactive experience. This unique experience stands out from the competition and is much less likely to be thrown out or forgotten by a future customer.

Let's Get Growing Blank Card Set of 5

A business card should contain only the necessary information about you, your company and at least two ways to contact your business. Any other information should be kept to a minimum or removed entirely. From handmade pieces to vintage treasures ready to be loved again, Etsy is the global marketplace for unique and creative goods. It’s also home to a whole host of one-of-a-kind items made with love and extraordinary care. While many of the items on Etsy are handmade, you’ll also find craft supplies, digital items, and more. Whether you work at a bigwig agency or as a freelancer, your business card should make a memorable first impression.

INcredulous Blue Bird Friend Sticker - decal sticker of blue bird - sticker of painting of bird

back of card design

The best paper for homemade cards depends on the specific design and purpose of the card. However, cardstock is generally considered to be the top choice for homemade cards. Cardstock is a heavy and durable paper that provides a sturdy base for various crafting techniques, such as stamping, embossing, and layering.

Don't Try Studio

A deck of 55 cards, celebrating hard boiled heroes, wise-cracking women, mean streets, guns and gums... Small cards featuring natural history subjects, given away with packets of sweet cigarettes. In the case of Lawrence & Cohen and Hart there was a commercial agreement with De La Rue dating back to L.I. Cohen to use Jones's designs, but as far as I know there was no equivalent arrangement with Goodall, and yet below we see a copy of one of Goodall's designs. As it is smaller than the original Goodall one, it, too, has probably been re-engraved.

This Pokemon card problem has finally been fixed after 25 years - Gamesradar

This Pokemon card problem has finally been fixed after 25 years.

Posted: Wed, 28 Feb 2024 08:00:00 GMT [source]

Each miniature work of art is sure to make a memorable impact -- or at the very least, make the recipient reluctant to simply toss it. When it comes to card inserts, a lightweight and smooth paper is typically used. This type of paper allows for easy writing and ensures that the insert does not add bulk or weight to the card. A popular choice for card inserts is a smooth and uncoated paper, such as regular printer paper or lightweight cardstock. These papers provide a clean and professional look while allowing the recipient to easily write or read the message inside the card.

Essential Design Tips for Beginners: Transform Your Skills and Create Stunning Graphics

Tighter margins mean less hand fatigue and better readability/playability. As with all competition, once one producer opens up a lucrative market, others will follow. Goodall also produced a fine series of back designs from the 1860s onwards in particular.

It’s also worth mentioning that the cards and tuck box don’t need to come from the same printer. Die cuts and non-standard papers would usually require ordering tuck boxes from one provider and cards from another. With this deck however, I did use Mr. Playing Card for both the cards and tuck box. An effective business card targets your audience and industry, is eye-catching without being hard to read and includes all the necessary information without too much clutter. Well-designed business cards will be unique, aesthetically pleasing and will communicate what you do effectively.

They use something like bargain S27 smooth card stock and only the card back can be customized. It’s the kind of garbage you’ll find in a coffee table drawer while on vacation at the beach. Designing a playing card deck has always been one of those bucket list items for me.

Monge Quentin, the Parisian illustrator behind Don't Try Studio, created these lively and colorful business cards to promote his design work. Thanks to an embossing technique, the face of the cards are embellished with confetti-like brush strokes and shapes in a muted orange and blue color scheme. Designed to promote a video game of the same name, these business cards are actually plantable.

Waddington took over the printing of all Goodall/De La Rue cards in 1941 after the De La Rue factory at Bunhill Row was destroyed in the Blitz. It's clear that several of the designs used by other makers take their inspiration from Owen Jones's work. Although De La Rue were credited with inventing the decorative back design, such claims were hotly disputed by Reynolds & Sons. At 18 he ran away and saw the world with a backpack and a credit card, discovering that the true value of any point or mile is the experience it facilitates. He remains most at home on a tractor, but has learned that opportunity is where he finds it and discomfort is more interesting than complacency.

Clubhouse Mickey Mouse Clubhouse Fandom

mickey mouse club house

Such as translating messages, creating a Mousekemap, delivering important items, and even changing color. At the beginning of every episode, Mickey uses the magic words to make the clubhouse appear. The magic words, Meeska Mooska Mickey Mouse, are derived from the Mickey Mouse Club. Should someone say the words incorrectly, the parts of the clubhouse will disconnect and float away, as is evident in one episode.

Contents

Visit the Disney+ Help Center to learn more about Disney+ through Spectrum support. Disney Bundle plans include subscriptions to either Disney+ and Hulu, or Disney+, Hulu, and ESPN+, at discounted prices, as compared to the retail price of each subscription when purchased separately. All of these and more now streaming on Disney+, Hulu, and ESPN+ with the Disney Bundle. After the show ended in 2016, it was succeeded by Mickey and the Roadster Racers (later renamed Mickey Mouse Mixed-Up Adventures), which ran from 2017 to 2021, and Mickey Mouse Funhouse, which started in 2021.

Disney Mickey Mouse

Once the puzzle is solved, two miniature Handy Helpers will pop up and applaud, and it will sprinkle confetti. Wondering where to watch Mickey Mouse Clubhouse Season 1 online? Mickey Mouse Clubhouse is an interactive children’s television show that originally aired in 2006. The show features the ever-so-enthusiastic Mickey Mouse and his pals Minnie, Goofy, Donald, Daisy, and Pluto, who embark on learning adventures. The Handy Helpers are self-controlled machines that resemble gloves of the famous characters created to do daily jobs such as cooking and cleaning. Not only do they work in the clubhouse, but they can also work anywhere and on anything.

Is Mickey Mouse Clubhouse Season 1 available to watch via streaming?

A successor to this series, Mickey Mouse Mixed-Up Adventures, originally Mickey and the Roadster Racers, debuted on January 15, 2017. It was then succeeded by Mickey Mouse Funhouse, which debuted on August 20, 2021. However, a special episode of this series premiered on July 16, 2021 before the series debut. And with ESPN+, you can stream live sports, thousands of live events, top leagues and tournaments, ESPN+ Originals, and the complete 30 for 30 Library. Plus, get exclusive access to premium articles, fantasy tools, and archives. The Disney+ app is available on mobile devices, web browsers, game consoles, set-top boxes, and smart TVs.

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Using early math learning and problem solving skills, he leads kids on an interactive adventure of learning and fun. Watch Mickey Mouse Clubhouse every morning at 8am/7c on Disney Junior on Disney Channel. At the end of every episode, the characters stand in front of the Mousekedoer during the Hot Dog Dance, during which the Mousekedoer twists around to the outside before the characters leave the clubhouse. Mickey Mouse Clubhouse Season 1 is available to watch on Disney Plus. Disney Plus is a streaming platform that provides its audience with access to all of the exclusive Disney content and more, including Frozen 2 and Bluey, among others.

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mickey mouse club house

Mickey Mouse, Minnie Mouse, Donald Duck, Daisy Duck, Goofy, and Pluto star in the series, taking place at the Clubhouse where most of the events in the series occur. The group also has a small, Mickey-head-shaped, flying super computer named Toodles that acts as an extension of the Mousekedoer and helps the gang with the given problems and carries tools that they might need. Pete, Clarabelle Cow, Ludwig Von Drake, Chip and Dale, Willie the Giant, Butch, Figaro, Humphrey the Bear, Salty the Seal, and Mortimer Mouse have made guest appearances. The series focuses on interacting with the viewer to stimulate problem solving. One of them is a "Mystery Mouseketool" represented by a Question Mark, in which, when the words "Mystery Mouseketool" are said, the question mark changes into the Mouseketool the viewer gets to use.

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You can walk through his living room, den, laundry room and back yard and greet him in his dressing room in the Movie Barn. You can watch a classic cartoon on the television, check out Mickey's collectibles which include a special photo of Mickey with his pal Walt Disney, and don't miss the oversized vegetables in the garden. The 'Mickeyologist' home in Los Angeles could be called the 'Mouse House.' It's filled with games, watched, toys, dolls, even an original Walt Disney business card. When ABC7's George Pennacchio asked Shine, "How many Mickey items do you think you've collected?" Shine had no idea, but he did share a desire to one day share all of his collectibles in some for or fashion. As he put it, "It's better when this kind of Mickey magic and joy is shared." In addition to the Main Living Area, Otherwise known as the “Anywhere Area”, there are other rooms located within the Clubhouse that can be accessed by merely pulling the Anywhere Lever.

Main

When ready to pick a Mouseketool, the gang shouts "Oh, Toodles!" to call Toodles, who pops up from where he is hiding and presents the set on-screen so the viewer can pick which tool Mickey and his friends need for the current situation, which usually works flawlessly. Mickey then directs his friends back to the Clubhouse to perform the Hot Dog Dance while the person with their issue fixed thanks viewers for their help and Toodles returns to his spot on the Mousekedoer, which spins around to the outside to allow everyone to leave. The Clubhouse then disappears as Mickey thanks viewers for their visit. The program was initially announced on March 1, 2005, by Gary Marsh, who is the Executive Vice President of Original Programming and Production for The Walt Disney Company. The characters debuted in CG form in 2003 at the Magic Kingdom attraction Mickey's PhilharMagic, then in the 2004 home video Mickey's Twice Upon a Christmas.

The only way to bring them back to its original spot is by touching each individual part of the clubhouse and saying the magic words exactly right and they will fly back to their original location. In another episode, a crystal known as the Crystal Mickey is revealed to be the source of the Clubhouse’s Meeska Mooska Magic. The Clubhouse disappears at the end of every episode once the whole group leaves. The Silly Switch is a large lever that causes something amazing or silly to happen depending on the theme of the episode when pulled,(hence the name "Silly Switch"). The Disney Plus Basic plan allows users to stream the service’s content with ads, while the Premium plan lets users stream with no ads and download content to supported devices. There are also a variety of bundle packages, scaling from Bundle Duo Basic, which pairs Disney Plus with Hulu for $9.99 per month, to the Disney Bundle Trio Premium for $19.99 per month, which bundles Disney Plus, Hulu, and ESPN Plus.

Mickey Mouse, Minnie Mouse, Donald Duck, Daisy Duck, Goofy and Pluto, the main stars of the show, interact with the viewers and go on problem-solving adventures. The group has a small, Mickey head-shaped flying super computer named Toodles that acts as an extension of the Mousekedoer and helps the gang with the given problems and carries tools that they might need. The series mainly focuses on interacting with the viewer to simulate problem solving. According to Disney, each episode has the characters help children solve a specific age-appropriate problem using basic skills, such as identifying shapes and counting from one to ten. This show is similar to other shows like Sesame Street, Pee-Wee's Playhouse, Dora the Explorer, and Zoobilee Zoo. The series uses "Disney Junior's common 'whole child' curriculum of cognitive, social and creative learning opportunities."

However, in this incarnation, Mickey's and Minnie's 3D renderings are truer to their original hand-drawn likenesses, in that their ears remain distinct perfect circles regardless of which way their heads are turned. The show features two original songs performed by They Might Be Giants, including the opening theme song and the closing song "The Hot Dog Song", which echoes Mickey's first spoken words in the 1929 short The Karnival Kid. Along with improved animation for the second season, the series transitioned into a widescreen HD format. All the episodes of this series, excluding Mickey's Great Clubhouse Hunt, are available on Disney+.

mickey mouse club house

It was revealed that Mickey and the gang think of the Handy Helpers as helpful friends and not servants. One Handy Helper is usually seen opening the front door for The Sensational Six and their friends. In one episode, the Handy Helpers begin to act crazy and stop working, and Mickey and the gang decide to help out, stating that the Handy Helpers are their friends. It was also revealed that the inner workings of the Handy Helpers come from the Handy Dandy Machine located in the basement underneath the Clubhouse which can be accessed by a down slide. The Mousekedoer is a special machine that runs on a special energy source called "Liquid Light" and is the main power source for Toodles, as revealed in "Mickey's Mousekedoer Adventure". Whenever the Sensational Six are about to set off on a fun adventure or important mission, the Mousekedoer provides them with special Mouseketools that will help them on their mission/adventure.

Disney+ is a streaming service where you can watch movies, series, and originals from Disney, Pixar, Marvel, Star Wars, Nat Geo, and more. Here’s how you can watch and stream Mickey Mouse Clubhouse Season 1 via streaming services such as Disney Plus. Specials, such as Mickey's Great Clubhouse Hunt, Road Rally, and A Goofy Fairy Tale (the series finale), have also been released over the course of the series. Wheelchairs should go up the ramp on the right side of the house. Cynics say the entire house is just a dressed-up queue to distract you from the sometimes long wait to meet the world's most famous mouse, but that's just fine with me.

The Mousekedoer usually provides between 3-5 Mouseketools per adventure/mission. On occasion, the Mousekedoer will provide Mouseketools unique for the adventure. For instance, in "Goofy's Thinking Cap," the Mousekedoer provided 4 Mouseke-Think-About-It Tools instead of the usual Mouseketools to help them think up any kind of tool they need. Another example was in "Mickey's Mystery" where each Mouseketool was hidden behind a pictogram to describe the Mouseketool needed for the mission. These tools are transferred into Toodles who would later distribute the tools to the gang when called upon. Besides providing the Mouseketools, the Mousekedoer is also known for many other things.

Friday, April 12, 2024

Cruise Terminals

horizon cruise terminal southampton

Cruise itineraries are subject to change, and will be confirmed by your booking agent at the time of booking. The winner of the second token collect competition was Lin Malt from Hampshire. Lin wins a 7-night cruise holidays offered by the terminal’s cruise partners, NCL. With nearly 4,000 name suggestions from across the world entered into a competition, Horizon Cruise Terminal was put forward by Anna Chojnacka having been chosen at random from multiple entries of the same name.

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Parking is available for passengers traveling from all five terminals. To guarantee your spot it's advisable to pre-book in advance, especially during the busy summer months from July to September when facilities do sell out on occasion due to high levels of bookings. Terms and conditions apply to all offers and prices displayed on this website. All fares are a guide (not live pricing) and subject to change without notice, please call for latest prices. Offers are capacity controlled and may be modified or withdrawn at any time.

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As you get past dock gate security, keep an eye out for signs directing you to Dock Gate 10; the Horizon terminal will be in front of you. ‘The success of this summer’s round-Britain cruises is a testament to the commitment shown by so many people working within cruise but also in ports, local authorities, health bodies and government. Using shore-side power cruise ships can turn off their engines in port to reduce pollution.

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The car parking service on offer for each cruise will depend on your cruise line operator and your departure and arrival terminal. Note that, typically, the longer the cruise, the cheaper the daily parking rate. The fifth dedicated cruise terminal at the port will benefit from roof-mounted solar power and will also have Shore Power connectivity installed. With construction on track, the port will be welcoming ships alongside from the summer. Cruise shuttle transfers provide a direct London to Southampton cruise terminal transfer in smart, executive vehicles. These are shared with up to eight other passengers, with a maximum of four hotel pick ups/drops offs.

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Although only a handful of passengers would attempt this minute walk with luggage. The five cruise terminals are managed by Southampton Port Authority. It is they who decide which cruise ship will use which terminal, not the cruise companies. Only one cruise ship can occupy a terminal and the same cruise company doesn't always use the same terminal.

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Local transport will bring you to the city centre and from there you must take a short taxi journey. A range of convenient London to Southampton transfers are available to Southampton's Queen Elizabeth cruise terminal from the capital and its airports. A range of convenient London to Southampton transfers are available to Southampton's Ocean cruise terminal from the capital and its airports. Southampton cruise terminals are not served by any public transport. The only way to reach them is by driving and booking long term cruise parking, taking a taxi or booking a cruise transfer.

horizon cruise terminal southampton horizon cruise terminal southampton

The terminal features the UK’s first shore power connection of its kind, enabling cruise ships with the right onboard connectivity to ‘plug in’ to green energy while alongside. Horizon’s shore power is expected to be commissioned later this year. There are no shuttle buses or public transport connecting any of Southampton's hotels to the cruise terminals. The City Cruise terminal is the only terminal within walking distance of any hotel, these are the Ibis, Ibis Budget, Novotel and Holiday Inn. The other Southampton cruise terminals require a short taxi journey, as they’re a little further along the waterfront. The Southampton map below clearly marks the four cruise terminals in relation to the city's other amenities.

Horizon Cruise Terminal is also fitted with more than 2,000 roof-mounted solar panels, which means that on a day-to-day basis it will generate more power than it uses. Public transport is also available from London to Southampton but this will drop you in the city centre. Our Southampton city map above illustrates the locations of the hotels and the four cruise terminals. The fifth terminal is a joint venture between MSC Cruises and Norwegian Cruise Line. These companies have signed partnership deals to use the facility, however it also accommodates luxury cruise lines Regent Seven Seas Cruise Lines and Oceania Cruises.

Director Alastair Welch said they had selected the name as the shape of the terminal roof was "such a distinctive silhouette on the horizon as you come through Dock Gate 10." According to the port's owner and operator ABP, with construction on track, the port would be operational in summer 2021. Those ads you do see are predominantly from local businesses promoting local services. We want our comments to be a lively and valuable part of our community - a place where readers can debate and engage with the most important local issues.

Located at Dock Gate 10, Southern Road is the new Horizon Cruise Terminal – a joint partnership between MSC Cruises and Norwegian Cruise Line. However, you will need to make sure that each bag/case is under 23KG – this is so that the people handling them can do so safely. Whilst the maximum cases are meant to be four per cabin, you can usually take one or two more if you are going on a much longer voyage – especially for repositioning or a world cruise. Sign up for our newsletter to stay on top of the latest news, blogs and offers.

Porters will assist you with your bags as you exit here if you are taking a taxi or a someone is dropping you off. The parking lot for the Horizon Cruise facility is outside the front of the facility. Porters will help you with your luggage once you've parked, and the staff will give you any necessary directions. Getting to the terminal is simple via vehicle or public transportation. As reported, the building is fitted with more than 2,000 roof-mounted solar panels. Owners ABP says it will generate more power than it uses on a day-to-day basis.

Whilst Southampton tour transfers offer a similar service but incorporate sight seeing along the way, such as to Stonehenge or Windsor Castle. Booking your own private Southampton cruise transfer is the most flexible option and can be surprisingly good value if there is a group of you. Private transfers allow you to dictate your own timings and can include sightseeing too. The closest hotels to the Queen Elizabeth terminal are in the old part of town. When you drive to the port, follow directions to Dock Gate 10 and Horizon Cruise Terminal (SO15 1HG) – simply put the parking voucher on your dashboard and you will be directed by the car park staff to exactly where you park. All cruises will depart from Southampton and whilst open to other nationalities this time around, embarkation will only be at the Port of Southampton and specifically, at their brand new cruise terminal – the Horizon Cruise Terminal.

The Port of Southampton’s newest cruise terminal was officially opened today by the Maritime Minister during London International Shipping Week. Courts met with Cruise Lines International Association UK & Ireland on the same day in Southampton as part of ongoing collaboration between the UK government and the cruise industry. Check if your cruise terminal has a security screening (City Cruise Terminal for example does this) before proceeding to check-in counters. Taxis are readily available at Southampton International Airport, Heathrow and Gatwick Airports.

The ability to comment on our stories is a privilege, not a right, however, and that privilege may be withdrawn if it is abused or misused. Now, Southampton's new £55m gateway to the city has been officially opened – despite more than 75,000 passengers already going through its doors. Joining the plaque unveiling was Anna Chojnacka Liberska, the winner of a public competition which attracted more than 4000 entries to name the terminal. The Horizon Cruise Terminal’s official opening takes place later this year; the port took delivery of the terminal's air bridge last month. The Horizon Cruise Terminal’s official opening takes place later this year; the port took delivery of the terminal’s air bridge last month.

Before checking in, you will need to go through security, so be prepared with your tickets and passport. Robert Courts MP unveiled the plaque, formally naming and opening the £55 million next-generation Horizon Cruise Terminal at an event to celebrate the Port of Southampton’s significant investment in the future of cruise. A second shore power connection is also being installed at The Mayflower terminal.

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